Can genetic testing take the trial and error out of prescribing anti-depressant medications?

First, let’s talk about what genetic testing actually is. According to the standard online definition, genetic testing is “the sequencing of human DNA in order to discover genetic differences, anomalies, or mutations that may prove pathological.” Basically, it looks at what makes you unique and why that may be of concern in the development and treatment of different diseases.

Finding the right medication to fit your needs can be a difficult and lengthy process. Because your DNA sequencing is unique, your depression (or another mental illness) may manifest itself differently than someone else’s. Genetic testing can provide insight into what medications will have a positive interaction with your body/genetic makeup.

I did not think I could effectively write this article without having my genes tested, so I did! I used the GeneSight testing service and describe my experience below. Please know that I have no relationship with GeneSight and I did not receive any form of compensation for this article.

Here’s how it’s done:

• It is a noninvasive test consisting only of a cheek swab.
• The DNA sample is sent to the lab to be analyzed.
• The results arrive at your doctor’s office within 36 hours.
• During a follow-up visit, you and your doctor discuss which medication will meet your needs and allow for the fewest possible side effects based on the results.

Benefits:

• The report is very comprehensive. I received a nine-page report that tested my gene-drug interactions and perceived efficacy for over fifty different antidepressants, antianxiety hypnotics, and mood stabilizers.
• You have the option to also test your folic acid conversion rates and have the same analysis done for prescription pain medications.
• If your insurance company does not cover the cost of the test (see challenges section below) your out of pocket cost is adjusted based on your income level.

Challenges:

• Not all medical professionals offer genetic testing. If you are interested in this process, ask your healthcare provider if they offer this service before making an appointment.
• The screening may come with a cost. Call your insurance company prior to the testing to see if they cover all or part of the cost.
• According to my friend and genetic expert, Kong Xoing, “GeneSight uses a genotyping method which looks at genes broadly. This method will show a correlation with a lot of patients, but not all. To have every patient receive 100% accurate interpretations, the testing service would have to sequence (interpret) the entire gene and not just certain parts, as they are doing. Sequencing the entire gene is a much greater cost.”

There are several pharmacogenomic testing services available. If you are interested in pursuing this form of testing, research your options and talk with your doctor about which option is best for you. For more information about GeneSight genetic testing visit genesight.com. 

*Note: InspireHopeBlog is not affiliated with GeneSight and does not receive compensation for this article.

Sending Strength & Hope,
HopeHeroesUnite.com